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A randomized prospective study of neonatal hepatitis B vaccine immunogenicity in The Gambia and Papua New Guinea

Protection of newborns from infection can be achieved through maternal or vaccine-induced antibodies, but the factors influencing vaccine protection (correlate of protection) and subsequent infant immunity remain insufficiently understood. Further investigation is essential to optimize early-life vaccination strategies.

Citation:
Diray-Arce J, Syphurs C, Hoch A, …….. Ben-Othman R, Shannon CP, ….. Kollmann TR, Kraft K, Larsen KL, …….. Pomat WS, Rao S, Roberts E, …….. Kollmann TR, Levy O, Richmond PC, van den Biggelaar AHJ, Kampmann B, et al. A randomized prospective study of neonatal hepatitis B vaccine immunogenicity in The Gambia and Papua New Guinea. J Allergy Clin Immunol Glob. 2026;5(3).

Keywords:
Vaccines; Expanded Program on Immunization; neonatal vaccination; hepatitis B vaccine; Bacille Calmette-Guérin; neonates; maternal antibodies; vaccine immunogenicity

Abstract:
Protection of newborns from infection can be achieved through maternal or vaccine-induced antibodies, but the factors influencing vaccine protection (correlate of protection) and subsequent infant immunity remain insufficiently understood. Further investigation is essential to optimize early-life vaccination strategies.