Reports and Findings
Research
Adenosine 2A Receptor Activation Amplifies Ibrutinib Antiplatelet Effect; Implications in Chronic Lymphocytic LeukemiaChronic lymphocytic leukemia patients have an increased bleeding risk with the introduction of Bruton tyrosine kinase (BTK) inhibitors. BTK is a signaling effector downstream of the platelet GPVI receptor. Innate platelet dysfunction in CLL patients and the contribution of the leukemia microenvironment to the anti-platelet effect of BTK inhibitors are still not well defined.
Research
Anoctamins and Calcium Signalling: An Obstacle to EGFR Targeted Therapy in Glioblastoma?Glioblastoma is the most common form of high-grade glioma in adults and has a poor survival rate with very limited treatment options. There have been no significant advancements in glioblastoma treatment in over 30 years. Epidermal growth factor receptor is upregulated in most glioblastoma tumours and, therefore, has been a drug target in recent targeted therapy clinical trials.
Research
Cancer therapies inducing DNA damageThe induction of DNA damage has been employed as an anticancer strategy for more than 100years, first starting with the use of radiation to treat stomach cancer followed by the first uses of DNA-damaging chemotherapy to treat childhood leukemia.
Research
Type I interferon subtypes differentially activate the anti-leukaemic function of natural killer cellsNatural killer (NK) cells have an intrinsic ability to detect and eliminate leukaemic cells. Cellular therapies using cytokine-activated NK cells have emerged as promising treatments for patients with advanced leukaemia. However, not all patients respond to current NK cell therapies, and thus improvements in efficacy are required.
Research
Innovative Playful Learning Approaches to Improve Children’s Readiness for Primary Education in UzbekistanThe Government of Uzbekistan has committed to reforming preschool education, prioritising upskilling teachers to use international best practice.
Research
Review of trends in disabilities, mental health disorders and complex needs among children and adolescentsThe aim of the project was to provide the South Australian Department for Education with a synthesis of high-quality evidence on the population prevalence of various disabilities among school-aged children.
Research
Learning Together and Learning Together at Home: Program Model ReviewLearning Together, developed by the South Australian Department for Education, aims to create enriched learning environments that can be transferred to the home to support positive changes for children and families.
Research
Early literacy skills: review of evidence for pedagogical approaches that best support children’s early literacy skillsRecent evidence indicates that a child’s home learning environment is the strongest predictor of success in later reading abilities and that for children not receiving structured language and reading support at home.
Research
School staff responses to student reports of bullying: A scoping reviewBullying in schools has been associated with poor academic and mental health outcomes in students. While students are often encouraged to report bullying incidents to school staff, some students avoid reporting incidents as they lack faith in staff members ability to intervene.
Research
Epstein–Barr virus infection, B-cell dysfunction and other risk factors converge in gut-associated lymphoid tissue to drive the immunopathogenesis of multiple sclerosis: a hypothesisMultiple sclerosis is associated with Epstein–Barr virus (EBV) infection, B-cell dysfunction, gut dysbiosis, and environmental and genetic risk factors, including female sex.