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Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagusBarrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia,...
Research
Statistical adjustment of genotyping error in a case-control study of childhood leukaemiaGenotyping has become more cost-effective and less invasive with the use of buccal cell...
Research
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagusBarrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly...
Research
Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locusWe found a novel association between intraocular pressure and a common variant at 7p21 near to GLCCI1 and ICA1.
Research
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetesMetformin is the most commonly used pharmacological therapy for type 2 diabetes. We report a genome-wide association study for glycemic response to metformin...
Research
Interleukin 10 gene polymorphisms and development of post kala-azar dermal leishmaniasis in a selected sudanese populationPost kala-azar dermal leishmaniasis (PKDL) is a cutaneous form of disease that develops at variable times after individuals have received treatment.
Research
Influence of Toxoplasma gondii on host cell functionToxoplasma gondii is a ubiquitous pathogen capable of infecting animals, including humans, & is a significant health burden in developed/developing countries
Research
Comparison of Methods to Account for Relatedness in Genome-Wide Association Studies with Family-Based DataHere we compare the performance of several LMM approaches (and software implementations, including EMMAX, GenABEL, FaST-LMM, Mendel, GEMMA and MMM) via their...
Research
TLR1/2 activation during Heterologous prime-boost vaccination (DNA-MVA) enhances CD8+ T cell responses providingLeishmania (Viannia) parasites present particular challenges, as human and murine immune responses to infection are distinct from other Leishmania species
Research
Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe)To investigate whether variants in cardiovascular candidate genes, some of which have been previously associated with type 2 diabetes (T2D), diabetic...