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Research

We therefore speculate that removal of wP from the vaccine schedule contributed to the observed rise in IgE-mediated food allergy among Australian infants

Effect of Posture on Lung Ventilation distribution and Associations with Structure in Children with Cystic Fibrosis Effect of Posture on Lung

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Research by The Kids Research Institute Australia will soon ensure young children are better protected against whooping cough.

We tested the hypothesis that treatment of CF epithelial cells with ivacaftor (Iva) or ivacaftor/lumacaftor (Iva/Lum) would improve control of rhinovirus infection.

This study aimed to explore the links between infection and where early damage due to CF is found in young children with CF. The results showed that

Investigating self-efficacy, disease knowledge and adherence to treatment in adolescents with cystic fibrosis Aim: Patient adherence is integral to

Use of a Primary Epithelial Cell Screening Tool to Investigate Phage Therapy in Cystic Fibrosis Antimicrobial-resistant microbes are an increasing

Research

This is a protocol for a Cochrane Review (intervention). The objectives were to assess the efficacy and safety of whole‐cell pertussis (wP) vaccinations in comparison to acellular pertussis (aP) vaccinations in early infancy for the prevention of atopic diseases in children.

Metabolomic Biomarkers Predictive of Early Structural Lung Disease in Cystic Fibrosis. ABSTRACT Neutrophilic airway inflammation plays a role in

Research

This phase 1 trial assessed the safety and immunogenicity of an investigational tetanus/diphtheria/acellular pertussis vaccine combined with CpG 1018 adjuvant 1500 μg (Tdap-1018 1500 μg) or 3000 μg (Tdap-1018 3000 μg) in adults and adolescents.

Oxidative stress and abnormal bioactive lipids in early cystic fibrosis lung disease. What did you find? We focused on lipid molecules which we know

Research

In many countries, infant vaccination with acellular pertussis (aP) vaccines has replaced use of more reactogenic whole-cell pertussis (wP) vaccines. Based on immunological and epidemiological evidence, we hypothesised that substituting the first aP dose in the routine vaccination schedule with wP vaccine might protect against IgE-mediated food allergy. We aimed to compare reactogenicity, immunogenicity, and IgE-mediated responses of a mixed wP/aP primary schedule versus the standard aP-only schedule.

Latest news & events at the Wesfarmers Centre of Vaccines & Infectious Diseases.

Phagocyte extracellular traps in children with neutrophilic airway inflammation Childhood lung infection is often associated with prominent

Research

The recent epidemics of pertussis (whooping cough) in parts of the USA and Australia have led to the largest numbers of annual cases reported in over half a...

Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic Fibrosis Individuals with cystic fibrosis (CF)

An adapted novel flow cytometry methodology to delineate types of cell death in airway epithelial cells Cystic fibrosis (CF) lung disease is

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Researchers from The Kids Research Institute Australia and Curtin University will use a $3.9 million grant from the National Health and Medical Research Council to investigate whether a type of whooping cough vaccine could provide bonus protection against food allergies and eczema.

Research

Small volume assays are required for large-scale research studies and in particular paediatric trials, where multiple measures are required from a single sample. Fluorescent bead-based technology (Bioplex/Luminex) allows high through-put and simultaneous quantification of multiple analytes in a single test. This technology uses sets of microspheres, each with a unique spectral address that can be coated with a different antigen of interest.