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Folate pathway gene polymorphisms and risk of childhood brain tumors: Results from an Australian case-control studyRecent research suggests that maternal folic acid supplementation is associated with a reduced risk of childhood brain tumors (CBT); polymorphisms in folate...
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Participation in population-based case-control studies: does the observed decline vary by socio-economic status?Participation in population-based case-control studies: does the observed decline vary by socio-economic status?
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Parental prenatal smoking and risk of childhood acute lymphoblastic leukemiaThe association between parental smoking and risk of childhood acute lymphoblastic leukemia (ALL) was investigated
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Meningiomas in children and adolescents: a meta-analysis of individual patient dataThe epidemiological, prognostic, and therapeutic features of child and adolescent meningioma are poorly defined...
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Determining risk features for medulloblastoma in the molecular eraNick Gottardo MBChB FRACP PhD Head of Paediatric and Adolescent Oncology and Haematology, Perth Children’s Hospital; Co-head, Brain Tumour Research
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Imaging of Abdominal Complications in Children With Acute Lymphoblastic LeukaemiaAcute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer-related death in children and adolescents. Five-year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens.
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Functional genomics in cancer immunotherapy: Computational approaches for biomarker and drug discoveryThis review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response
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novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunctionThis study thus identified a novel small molecule that rapidly kills MLL-rearranged leukemia cells by targeting a metabolic vulnerability
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A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia PathogenesisHere we report that CHAF1B is required for normal hematopoiesis while its overexpression promotes leukemia
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Recurrent MET fusion genes represent a drug target in pediatric glioblastomaWe identified previously unidentified gene fusions involving the MET oncogene in pediatric glioblastoma