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News & Events
Winners Announced: 2021 Inspiration AwardsMEDIA ENQUIRIES Media Contacts About the Wal-yan Respiratory Research Centre Please direct general enquiries to our reception on (08) 6319 1000.
News & Events
20-year MAVRIC study celebrates recruitment of its 1000th participantThe MAVRIC (Mechanisms of Acute Viral Respiratory Infection in Children) study recently celebrated the recruitment of the 1000th participant to the study, eight-year-old Sullivan Strahan.
News & Events
Vertex grants to support advances in cystic fibrosis careTwo outstanding researchers from the Wal-yan Respiratory Research Centre have been awarded Vertex Cystic Fibrosis (CF) Mentored Innovation Research Awards.
News & Events
New trial aims to nip chronic lung disease in the bud for First Nations kidsWA researchers will use a $1.97 million Medical Research Future Fund grant to develop a strategy for better follow-up of First Nations children after they’ve been hospitalised for respiratory infections, in a bid to halt the slide into more severe lung disease.
News & Events
Research to explore promising new RSV treatment supported by innovation seed fundingResearchers from the Wal-yan Respiratory Research Centre are collaborating with Virex Pharma to undertake vital research into a potential breakthrough treatment for RSV infections in young children, thanks to a $499,241 grant awarded by the WA Department of Health Innovation Seed Fund.
News & Events
Fellowship to support research into ways to improve the lung health of people born pretermWal-yan Respiratory Research Centre researcher Ms Denby Evans has been awarded one of four inaugural fellowships supported by the State's Future Health Research and Innovation (FHRI) Fund and Brightspark Foundation, enabling her to further her research into ways to improve the lung health of people
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Research
Suppression of TGF-β/SMAD signaling by an inner nuclear membrane phosphatase complexCytokines of the TGF-β superfamily control essential cell fate decisions via receptor regulated SMAD (R-SMAD) transcription factors. Ligand-induced R-SMAD phosphorylation in the cytosol triggers their activation and nuclear accumulation. We determine how R-SMADs are inactivated by dephosphorylation in the cell nucleus to counteract signaling by TGF-β superfamily ligands.
Research
Profiling epithelial viral receptor expression in amniotic membrane and nasal epithelial cells at birthChildren with wheeze and asthma present with airway epithelial vulnerabilities, such as impaired responses to viral infection. It is postulated that the in utero environment may contribute to the development of airway epithelial vulnerabilities.
Research
Phage cocktail amikacin combination as a potential therapy for bacteremia associated with carbapenemase producing colistin resistant Klebsiella pneumoniaeThe increasing occurrence of hospital-associated infections, particularly bacteremia, caused by extensively drug-resistant (XDR) carbapenemase-producing colistin-resistant Klebsiella pneumoniae highlights a critical requirement to discover new therapeutic alternatives. Bacteriophages having host-specific bacteriolytic effects are promising alternatives for combating these pathogens.