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Characterization of “bystander” effects of the diphtheria-pertussis-tetanus (DTP) vaccine on the IgE systemWe are seeking more detailed information on how the immune system of infants responds to the vaccine, with the aim of identifying which aspects of the immune r
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Relationship between cytokine expression patterns and clinical outcomes: two population-based birth cohortsOur findings suggest that positive HDM 'allergy tests' and asthma are associated with a broad range of immunophenotypes, which may have important...
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Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophagesHuman peripheral blood monocytes were differentiated into uncommitted macrophages (M0) and then polarized to M1 and M2 phenotypes using LPS/IFN-gamma...
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Tracking of Vitamin D status from childhood to early adulthood and its association with peak bone massThere are moderate associations between vitamin D status measured in prepuberty, adolescence, and early adulthood
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Mannitol challenge testing for asthma in a community cohort of young adultsWe aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort.
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Quantification of Serum Ovalbumin-specific Immunoglobulin E Titre via in vivo Passive Cutaneous Anaphylaxis AssayWe describe herein a highly reproducible in vivo passive cutaneous anaphylaxis assay using Sprague Dawley rats for the quantification of ovalbumin-specific IgE
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Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmaticsOur findings provide new insight into the molecular mechanisms operative at baseline in the airway mucosa in atopic asthmatic with natural aeroallergen exposure
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Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescentsUsing prospective data from the Western Australian Pregnancy Cohort (Raine) Study, we investigated vitamin D status and predictors of serum 25-hydroxyvitamin...
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Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthmaNo reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence...
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Risk factors for bronchial hyperresponsiveness in teenagers differ with sex and atopic statusSex-related differences in bronchial hyperresponsiveness (BHR) have been reported in adolescents, but the mechanisms remain obscure.