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Durvalumab with first-line chemotherapy in previously untreated malignant pleural mesothelioma (DREAM): a multicentre, single-arm, phase 2 trial with a safety run-inThere is a strong unmet need to improve systemic therapy in mesothelioma. Chemotherapy with cisplatin and pemetrexed improves survival in malignant pleural mesothelioma, and immune checkpoint inhibitors are an emerging treatment in this disease. We aimed to evaluate the activity of durvalumab, an anti-PD-L1 antibody, given during and after first-line chemotherapy with cisplatin and pemetrexed in patients with advanced malignant pleural mesothelioma.
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CFC ReportThe Tasmanian Government has made a significant commitment in recent years to ensure children have the best possible start in life.
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Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy ResponsesImmunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond. Understanding immune mechanisms that underlie responsiveness to ICT will help identify predictive biomarkers of response and develop treatments to convert non-responding patients to responding ones. ICT primarily acts at the level of adaptive immunity. The specificity of adaptive immune cells, such as T and B cells, is determined by antigen-specific receptors.
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Start smart: a program for healthy mobile technology use by young childrenInvestigators: Donna Cross External collaborators: Leon Straker (Curtin University of Technology), Erin Howie (Curtin University of Technology),
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Functional genomics in cancer immunotherapy: Computational approaches for biomarker and drug discoveryThis review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response
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WA Aboriginal Child Health Survey (WAACHS) Linked Data StudyThis study is a partnership between researchers, the Aboriginal community and government to provide evidence for policy and practice addressing high priority health and wellbeing issues for Aboriginal children and families.
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A Pre-Clinical Assessment of the Pan-ERBB Inhibitor Dacomitinib in Pediatric and Adult Brain TumorsGlioblastoma in adults, and medulloblastoma and pineoblastoma that mainly affect children, are aggressive brain tumors.
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Disruptive mood dysregulation disorderThe new diagnostic category of disruptive mood dysregulation disorder (DMDD) was introduced in DSM-5
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Resident CD8+ and Migratory CD103+ Dendritic Cells Control CD8 T Cell Immunity during Acute Influenza InfectionThe identification of the specific DC subsets providing a critical role in presenting influenza antigens to naïve T cell precursors remains contentious and...
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Why do psychiatric patients have higher cancer mortality rates when cancer incidence is the same or lower?People with mental illness are no more likely than the general population to develop cancer but more likely to die of it
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The health-related quality of life of lung cancer patients with EGFR-The Kids-related skin adverse drug reactions and its relationship with coping style and self-managementThe status and associated factors of the health-related quality of life of non-small-cell lung cancer patients under targeted anti-cancer therapy have not been investigated. Self-management and coping style have been proven to be closely related to patients’ health-related quality of life.
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Early vocabulary development: The importance of joint attention and parent-child book readingThe current study brought a bioecological approach to children’s early vocabulary development using data from the Longitudinal Study of Australian Children...
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A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrenceRecurrences frequently occur following surgical removal of primary tumors. In many cancers, adjuvant therapies have limited efficacy. Surgery provides access to the tumor microenvironment, creating an opportunity for local therapy, in particular immunotherapy, which can induce local and systemic anti-cancer effects.
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Late-talking and risk for behavioral and emotional problems during childhood and adolescenceAlthough many toddlers with expressive vocabulary delay ("late talkers") present with age-appropriate language skills by the time they are of school age,...
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Early mental health morbidity and later smoking at 17 years of ageWe examined the relationship between the onset and pattern of childhood mental health disorders and subsequent current smoking status at age 17 years.
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Change in Dental Visits Among Eligible Children Under the Impact of the Child Dental Benefits Schedule in AustraliaIn Australia, although there have been some improvements, child oral health continues to be a major public health issue. The Australian Government introduced the means-tested Child Dental Benefits Schedule (CDBS) in 2014 to support access to dental services for children and adolescents aged 0-17 years from low-income families.