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Research

Current treatments for respiratory infections are severely limited. Ethanol's unique properties including antimicrobial, immunomodulatory, and surfactant-like activity make it a promising candidate treatment for respiratory infections if it can be delivered safely to the airway by inhalation. Here, we explore the safety, tolerability, and pharmacokinetics of inhaled ethanol in a phase I clinical trial.

Research

Accumulating evidence indicates that an early, robust type 1 interferon (IFN) response to SARS-CoV-2 is important in determining COVID-19 outcomes, with an inadequate IFN response associated with disease severity. Our objective was to examine the prophylactic potential of IFN administration to limit viral transmission.

Research

Evidence suggests the involvement of the microbiota, including oral, intra-tumoral and gut, in pancreatic cancer progression and response to therapy. The gut microbiota modulates the bile acid pool and is associated with maintaining host physiology. Studies have shown that the bile acid/gut microbiota axis is dysregulated in pancreatic cancer.

News & Events

Two leading researchers from The Kids received significant endorsements to advance their research at last night’s Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science (TSANZSRS) Annual Scientific Meeting in Adelaide.

News & Events

Congratulations to respiratory health researcher and clinician Dr Pam Laird, who was last night named joint winner of Early Career Scientist of the Year at the 2024 Premier’s Science Awards.

Research

The marked heterogeneity in cystic fibrosis (CF) disease complicates the selection of those most likely to benefit from existing or emergent treatments. We aimed to predict the progression of bronchiectasis in preschool children with CF.

Research

Laboratory models provide an important tool in helping to understand the cellular and molecular drivers of respiratory disease. Many animal models exist that model the neonatal outcomes of preterm birth.

Research

There is no consensus on how best to measure responses to interventions among children and adults with cystic fibrosis (CF). We have systematically reviewed and summarised the characteristics and measurement properties of tests and tools that have been used to capture outcomes in studies among people with CF, including their reliability, validity and responsiveness. This review is intended to guide researchers when selecting tests or tools for measuring treatment effects in CF trials. A consensus set of these tests and tools could improve consistency in how outcomes are captured and thereby facilitate comparisons and synthesis of evidence across studies.

Research

In this cohort, as compared with the AREST CF cohort, the authors highlight the limited correlation between infection and inflammation with lung function and structural impairment, and that this was mainly explained by the mild changes identified in lung function and on chest CT scan.

Research

In this study we assessed the effects of antigen exposure in mice pre‐sensitized with allergen following viral infection on changes in lung function, cellular responses and tight junction expression.

News & Events

Control IQ (CIQ) is an advanced hybrid closed loop system designed to ease the burden and stress involved in the daily decision making around diabetes management.

News & Events

The Children’s Diabetes Centre at Perth Children’s Hospital is excited to announce that we have successfully acquired limited supplies of the Dexcom G6 continuous glucose monitoring system.

News & Events

Meet Winter and Fox. The siblings are the first two participants in Australia to become involved in a new study using continuous glucose monitoring for measuring blood glucose levels in children at high risk of developing type 1 diabetes but who are not yet showing clinical signs of the condition.

News & Events

Our head of epidemiology research Dr Aveni Haynes and exercise researcher Dr Wayne Soon were lucky enough to be invited to Perth Children’s Hospital School to discuss type 1 diabetes and the research we are doing here at the Children’s Diabetes Centre.

News & Events

The aim of this study is to explore the experience of stigma in adolescents with type 1 diabetes and its association with diabetes self-management and glycaemic control.

News & Events

The Dexcom G6 Continuous Glucose Monitoring (CGM) system has been approved by the Therapeutic Goods Administration (TGA) for use in Australia.

News & Events

Due to COVID-19, diabetes clinics across WA run by the Diabetes Service at Perth Children's Hospital are now using telehealth. We would like to take this opportunity to evaluate the use of telehealth for clinics.

News & Events

One of the biggest challenges of having a child with a chronic illness during social isolation is the lack of respite for parents.

News & Events

We know many families have questions about the risk of COVID-19 to children with type 1 diabetes. To address these questions, Perth Children’s Hospital’s Diabetes Clinic has provided information and resources to help you navigate this tricky period.

News & Events

Our research team have been working with young people with type 1 diabetes to design and develop an app that contains guidelines and advice for what to do when you are being physically active.