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Research
Parental occupational exposure to engine exhausts and childhood brain tumorsParental occupational exposure to engine exhausts and childhood brain tumors.
Research
Parental occupational exposure to exhausts, solvents, glues and paints, and risk of childhood leukemiaIt is unknown whether parental occupational exposure to chemicals before during and after pregnancy increases the risk of acute lymphoblastic...
Research
Fetal growth and childhood acute lymphoblastic leukemia: Findings from the childhood leukemia international consortiumThe evidence that accelerated fetal growth is associated with a modest increased risk of childhood ALL is strong and consistent with known biological...
Research
Parental occupational exposure to engine exhausts and childhood brain tumorsIncreased risks were observed for maternal exposure to diesel exhaust any time before the child's birth and paternal exposure around the time of the child's...
News & Events
The Kids cancer researcher named a Superstar of STEMThe Kids Research Institute Australia brain cancer researcher, Dr Jessica Buck will today join the ranks of a select group of brilliant female scientists.
News & Events
How to win friends and influence people: Cancer researchers talk the talk for big resultsIn the field of cancer research, lobbying efforts by the The Kids Cancer Centre have contributed to major initiatives including Australia’s first personalised medicine program for children with high-risk cancer, and a mission to boost survival rates in brain cancer patients.
News & Events
Funding boost to melanoma researchA The Kids Research Institute Australia researcher will investigate new ways to harness the body’s own immune system to fight melanoma, thanks to Cancer Council WA funding.
News & Events
Adventurers deliver on a promise to help kids with cancerA state of the art 3D molecular imager that will help researchers monitor how brain tumours grow has been delivered to the Telethon Institute.
Research
IDH-mutant gliomas in children and adolescents - from biology to clinical trialsGliomas account for nearly 30% of all primary central nervous system (CNS) tumors in children and adolescents and young adults (AYA), contributing to significant morbidity and mortality. The updated molecular classification of gliomas defines molecularly diverse subtypes with a spectrum of tumors associated with age-distinct incidence.
Research
Disruption of cotranscriptional splicing suggests that RBM39 is a therapeutic target in acute lymphoblastic leukemiaThere are few options for patients with relapse/refractory B-cell acute lymphoblastic leukemia, thus this is a major area of unmet medical need. Here, we reveal that inclusion of a poison exon in RBM39, which could be induced both by CDK9 or CDK9 independent CMGC (cyclin-dependent kinases, mitogen-activated protein kinases, glycogen synthase kinases, CDC-like kinases) kinase inhibition, is recognized by the nonsense-mediated mRNA decay pathway for degradation.