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A novel role for interleukin-1 receptor signaling in the developmental regulation of immune responses to endotoxinSuggests that IL-1R1 expression provides an additional level of Myd88-dependent signaling during this period of heighted susceptibility to infection.
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Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditionsOne explanation for the high burden of allergic and autoimmune diseases in industrialized countries is inappropriate immune development under modern...
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The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhoodThis study examined whether maternal and/or fetal folate status in pregnancy is associated with infant allergic outcomes.
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World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): ProbioticsPrevalence of allergic diseases in infants, whose parents and siblings do not have allergy, is approximately 10% and reaches 20-30% in those with an allergic...
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Nature Connection: Providing a Pathway from Personal to Planetary HealthThe vast and growing challenges for human health and all life on Earth require urgent and deep structural changes to the way in which we live. Broken relationships with nature are at the core of both the modern health crisis and the erosion of planetary health. A declining connection to nature has been implicated in the exploitative attitudes that underpin the degradation of both physical and social environments and almost all aspects of personal physical, mental, and spiritual health.
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Macronutrients in Human Milk and Early Childhood Growth—Is Protein the Main Driver?Infant growth trajectories reflect current health status and may predict future obesity and metabolic diseases. Human milk is tailored to support optimal infant growth. However, nutrient intake rather than milk composition more accurately predicts growth outcomes. Although the role of protein leverage in infant growth is unclear, protein intake is important for early infancy growth.
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Cord blood t cells expressing high and low pkcζ levels develop into cells with a propensity to display th1 and th9 cytokine profiles, respectivelyow Protein Kinase C zeta (PKCζ) levels in cord blood T cells (CBTC) have been shown to correlate with the development of allergic sensitization in childhood. However, little is known about the mechanisms responsible. We have examined the relationship between the expression of different levels of PKCζ in CBTC and their development into mature T cell cytokine producers that relate to allergy or anti‐allergy promoting cells.
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The PLAN Project (Pregnancy Lifestyle Activity and Nutrition)Susan Prescott MBBS BMedSci PhD FRACP Honorary Research Fellow susan.prescott@thekids.org.au Honorary Research Fellow Susan Prescott is a Professor
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Water Quality and the Microbiome Study (TUMS): The effects of chlorinated drinking water on the assembly of the infant gut microbiomeDavid Debbie Desiree Matt Susan Martino Palmer Silva Cooper Prescott BSc PhD BSc BND PhD MBBS, FRACP, MPH, PhD BCA Marketing, BSc Statistics and
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Dimensions of the diet-exercise relationship in later life: A qualitative studyDiet and physical activity are two lifestyle behaviours that are critical for healthy ageing. The aim of this study was to explore how older adults negotiate dietary and physical activity decisions to identify areas of intersection between these two behaviours and inform health promotion interventions targeting both diet and exercise.