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Research

Editorial overview: Endocrine and metabolic adaptations to extreme environments: Living life to the extreme – insights into the limits of life and transitions to disease

The need to understand responses to extreme environments has prompted this edition of Current Opinion in Endocrine and Metabolic Research

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Mapping Tuberculosis Prevalence in Ethiopia: Protocol for a Geospatial Meta-Analysis

In this report, we present a protocol for a geospatial meta-analysis to investigate the spatial patterns of TB prevalence in Ethiopia

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Reviewing the Pathogenic Potential of the Otitis-Associated Bacteria Alloiococcus otitidis and Turicella otitidis

There is insufficient evidence available to determine whether these organisms are pathogens, commensals or contribute indirectly to the pathogenesis of OM

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Potent antileukemic activity of curaxin CBL0137 against MLL-rearranged leukemia

The aim of our study was to investigate whether CBL0137 has potential as a therapeutic and chemopotentiating compound in MLL-r leukemia

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Sensitizing the Tumor Microenvironment to Immune Checkpoint Therapy

In this review we explore the current literature about the predictive characteristics of the tumor microenvironment and discuss therapeutic approaches

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The relationship between abdominal pain and emotional wellbeing in children and adolescents in the Raine Study

Abdominal pain in children and adolescents associates with depression, anxiety, being bullied, unhappiness and reduced overall health-rating during adolescence

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Clinical characteristics of Western Australian children diagnosed with type 2 diabetes before 10 years of age

We aimed to describe the characteristics of Western Australian children aged less than 10 years diagnosed with type 2 diabetes between June 2000 and June 2017

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Sharing is Caring: A Study of Food-Sharing Practices in Australian Early Childhood Education and Care Services

This paper supports the practice of food sharing in Early Childhood Education and Care settings and calls for them to become embedded in everyday operations

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Ascertaining infectious disease burden through primary care clinic attendance among young Aboriginal children living in four remote communities in Western Australia

Improved public health measures targeting bacterial skin infections are needed to reduce this high burden of skin infections in Western Australia

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The NICE-GUT trial protocol: A randomised, placebo controlled trial of oral nitazoxanide for the empiric treatment of acute gastroenteritis among Australian Aboriginal children

Diarrhoeal disease is the second leading cause of death in children under 5 years globally, killing 525 000 annually. Australian Aboriginal and Torres Strait Islander (hereafter Aboriginal) children suffer a high burden of disease.